Histospectrophotometric characteristics of renal cell cancer (based on the data on DNA content)
Loginov, V.A.
Arkhiv Patologii 48(7): 24-30
1986
ISSN/ISBN: 0004-1955 PMID: 3753247 Document Number: 268380
Histospectrophotometric study of DNA content in hypernephroma has shown that specificity of DNA distribution is related rather to the degree of tumour differentiation than to its morphologic appearance. Thus, diploidy, characteristic of high differentiated cancer, in line with lower differentiation degree is followed by the prevailing tetraploid and octaploid cells, the emergence of polyploid cell clone, reflecting marked wide-range aneuploidy on the DNA histogram. Moderately differentiated variants of hypernephroma, according to the pattern of DNA distribution, occupy the intermediate position, approximating either to high differentiated, or low differentiated tumours.