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Comparative evaluation of the clinical course and dynamics of the morphological changes in chronic glomerulonephritis

Tov, N.L.; Valentik, M.F.; Vlazneva, V.A.; Kagalovskaia, I.M.; Nesina, I.A.

Terapevticheskii Arkhiv 58(8): 10-13

1986

ISSN/ISBN: 0040-3660
PMID: 3764748
Document Number: 267923
The results of a simultaneous study of a clinical and morphological course of chronic glomerulonephritis (CGN) in 30 patients after repeated morphological investigation of the renal tissue showed that a prevailing tendency in this disease was the progression of morphological changes which could be noted in a stable clinical picture and even in clinical improvement. The detection of tubulointerstitial changes in the first nephrobiopsy was an unfavorable prognostic factor. Of the greatest importance for indirect assessment of a morphological course of CGN were changes in creatinine clearance, effective renal plasma flow and arterial pressure. A morphological course of different variants of CGN and the effect of pathogenetic therapy on it were analyzed.

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