Biliary excretion of acetaminophen in diabetic and hyperthyroid rats
Siegers, C.P.; Loeser, W.; Younes, M.
Research Communications in Chemical Pathology and Pharmacology 47(3): 345-355
1985
ISSN/ISBN: 0034-5164 PMID: 3158040 Document Number: 264848
In streptozotocin-induced diabetic rats the biliary excretion of total acetaminophen (AA) was reduced to 14.1% of the dose (100 mg/kg i.v.) as compared to 24.6% in controls. This was due to a significant decrease in the amounts of AA-sulfate and AA-glucuronide, whereas the AA-GSH for 4 days) no significant alterations in the total AA or AA-conjugate excretion into bile were observed; moreover bile flow in hyperthyroid rats was in the same range as for controls. In all, known changes in hepatic microsomal or cytosolic enzyme and cosubstrate concentrations during the diabetic or hyperthyroid state do not at all correlate with their influence on the biliary excretion of AA and its conjugates.