A case of postpartum hemolytic uremic syndrome with severe elevations of liver enzymes
Sagawa, N.; Kariya, M.; Kanzaki, H.; Fujii, S.; Matsuura, S.; Mori, T.
Obstetrics and Gynecology 65(5): 761-764
1985
ISSN/ISBN: 0029-7844 PMID: 3920596 Document Number: 264840
An unusual case of multifocused postpartum thrombotic microangiopathy was encountered in a woman with pregnancy-induced hypertension, which presented clinical features different from those generally seen in postpartum hemolytic uremic syndrome or thrombotic thrombocytopenic purpura. These changes included acute disseminated intravascular coagulation, severe elevations of liver enzymes, severe renal dysfunction, and hemolytic anemia. The patient was treated successfully with heparin, gabexate mesilate, furosemide, fresh whole blood, and large doses of corticosteroid with antibiotics, and she recovered completely without sequelae. The hypothetical pathogenesis of the complex symptoms of this catastrophic clinical condition is proposed.