Phenytoin effects on liver and kidney structure of the rat
García-Estrada, J.; Tapia-Arizmendi, G.; Navarro-Ruiz, A.; Feria-Velasco, A.; Garzón-de la Mora, P.
Archivos de Investigacion Medica 16(1): 1-10
1985
ISSN/ISBN: 0066-6769 PMID: 4015293 Document Number: 264565
Anticonvulsants may induce severe undesirable side effects. Therefore, the morphological changes induced by phenytoin in rats were studied. Sodium-phenytoin was orally administered to adult Sprague Dawley rats at doses of 2.5, 5, 10, 15, 20, 50, 100 and 150 mg/kg throughout 7, 14 and 30 days. The cerebellum, brain, liver, kidney and small bowell were histologically studied. Liver showed intracellular large and fine fat droplets. Portal spaces contained plasma cells. Mononuclear cells infiltrated the liver parenchyma. The kidneys showed nonspecific chronic pyelonephritis, cloudy swelling, hemosiderine and lysed erythrocytes within convoluted and collecting ducts. The remaining tissues were found morphologically normal. Phenytoin apparently induced nonspecific inflammatory and degenerative changes in liver and kidney tissues.