In vitro motility of a population of clinical Burkholderia pseudomallei isolates
Boonbumrung, K.; Wuthiekanun, V.; Rengpipat, S.; Day, N.P.J.; Peacock, S.J.
Journal of the Medical Association of Thailand 89(9): 1506-1510
2006
ISSN/ISBN: 0125-2208 PMID: 17100392 Document Number: 2642
Melioidosis, a serious infection caused by Burkholderia pseudomallei, is a leading cause of community-acquired sepsis in Northeast Thailand, and the commonest cause of death from community-acquired pneumonia in the Top End of Northern Australia. The causative organism is a Gram-negative, motile bacillus that is a facultative intracellular pathogen. B. pseudomallei flagella have been proposed as a possible vaccine candidate and putative virulence determinant. Flagella expression was highly conserved for 205 clinical B. pseudomallei isolates, as defined by in vitro swim and swarm motility assays. No association was found between motility and clinical factors including bacteremia and death.
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