Successful sodium thiosulphate treatment for recurrent calcium urolithiasis
Yatzidis, H.
Clinical Nephrology 23(2): 63-67
1985
ISSN/ISBN: 0301-0430 PMID: 3886226 Document Number: 263041
Idiopathic rapid calcium stone formers (24 male/10 female) were studied. Their ages ranged from 20-60 yr (40 .+-. 11) and all had good renal function. The trial comprised 2 consecutive periods of 3 years and 4 years duration, respectively. In the first (control period), the patients were maintained on a customary diet with an adequate fluid intake sufficient to produce .apprx. 2 l of urine dialy. In the 2nd (treatment period), they received a similar diet plus 20 mmol of sodium thiosulfate daily. New stone development fell from 100 in the control period to 15 in the treatment period, corresponding to a rate of 0.98 and 0.11/yr (P < 0.001). Apparently, the benefit from sodium thiosulfate results from calcium thiosulfate formation in urine, a salt with a molar solubility of 250- to 100,000-fold greater than that of other urinary Ca salts.