Hexacarbon neuropathy: tracking a toxin
Couri, D.; Milks, M.M.
Neurotoxicology 6(4): 65-71
1985
ISSN/ISBN: 0161-813X PMID: 3003628 Document Number: 262842
This paper will present the progression of hexacarbon studies which followed the investigation of circumstances surrounding the occurrence of peripheral neuropathy in an occupational setting. The identification of methyl n-butyl ketone as the neurotoxin led to systematic studies of the biotransformation and mechanism of neurotoxicity. A consistent line of evidence showed that the neurotoxic potential of hexacarbons is directly related to the formation of the gamma-diketone metabolite, 2,5-hexanedione. The precise nature of the chemical interaction at the neurofilament is the subject of continuing investigation.
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