Cutaneous and muscular lesions following acute irradiation in swine. Histological and histoenzymological study
Lefaix, J.L.; Verola, O.; Daburon, F.; Brocheriou, C.
Annales de Pathologie 5(4-5): 249-258
1985
ISSN/ISBN: 0242-6498 PMID: 3833245 Document Number: 262364
Our present results were obtained in a histological and histoenzymological study done with an experimental porcine model of high dose local irradiation. This model was chosen to simulate accidents which occurred among humans. It enabled the determination of several post-irradiation phases. After an initial phase, with superficial lesions, ischemic necrosis occurred three weeks after irradiation. After two months, expanding necrosis became obvious in the muscular region preceded by an initial spread of vascular lesions. Histo-enzymological studies of the muscular tissue show metabolic alterations which precede histological modifications. Finally, sclerosis observed was characterized by its mutilating pseudo-sarcomatous aspect.