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Role of hexosemonophosphate shunt pathway in glucose metabolism in developing human foetal brain

Sengupta, T.; Datta, C.; Dasgupta, J.; De, K.; De, S.; Sengupta, D.

Indian Journal of Biochemistry and Biophysics 22(4): 208-210

1985

ISSN/ISBN: 0301-1208
PMID: 3833657
Document Number: 261904
The significance of hexosemonophosphate shunt (HMP) to the metabolic degradation of glucose in developing human foetal brain has been recognized by determining the activities of glucose-6-phosphate dehydrogenase (G6PDH), 6-phosphogluconate dehydrogenase (6PGDH) and tranketolase. Both the cerebrum and cerebellum show high level of activities at the early period, particularly, between 18th and 24th weeks of gestational ages, coinciding with the rapid rate of nucleic acid and lipid biosynthesis at this phase. This observation in turn reveals the involvement of HMP pathway in neuronal growth of human foetus.

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