Comparative quantitative assessment of a carcinogenic effect taking intercurrent mortality into account
Turusov, V.S.; Parfenov, I.D.
Voprosy Onkologii 31(2): 84-94
1985
ISSN/ISBN: 0507-3758 PMID: 3976212 Document Number: 261788
The paper discusses the advantages offered by the statistical evaluation of experimental carcinogenic effect with due regard to mortality from concomitant pathology. The method used complex tables of contingents and analysis was carried out separately in 3 groups of tumors--independent of mortality, fatal and incidental ones. The method was compared with standard procedures which do not take care of the said mortality rate (table of contingents 2 X 2 and precise procedure of Fisher). The data on development of 1,2-dimethylhydrazine-induced tumors of the skin, uterus and ovaries in 5 strains of mice were used in the study.