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Distribution of the kinin-breakdown activity in areas of the rat brain in the dynamics of spontaneous hypertension

Petriĭ, O.P.; Gomazkov, O.A.; Vladimirova, N.I.

Biulleten' Eksperimental'noi Biologii i Meditsiny 100(12): 649-652

1985

ISSN/ISBN: 0365-9615
PMID: 4074857
Document Number: 261630
Kinin-damaging activity (KDA) has been studied in 8 brain areas of normotensive rats and rats with spontaneous hypertension, aged 3 to 12 months. A significant depression in KDA was revealed in midbrain, striatum, thalamus, and pituitary body of normotensive rats 6 months of age, as compared to 3-month-old animals. A tendency towards KDA increase was noted in the hypothalamus. In 12-month-old normotensive rats KDA level returned to baseline (3 months of age). Comparison of KDA in rats with spontaneous hypertension aged 3 to 12 months has revealed no age-dependent differences and it is, therefore, believed that rats with spontaneous hypertension lack certain mechanisms inducing a considerable decrease of KDA in 6-month-old normotensive rats.

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