New approach of the treatment of von Willebrand's disease during pregnancy
Gojnic, M.; Fazlagic, A.; Likic, I.; Stefanovic, A.; Vidakovic, S.; Pervulov, M.; Petkovic, S.; Mostic, T.; Miljic, P.; Bogdanovic, A.
Archives of Gynecology and Obstetrics 273(1): 35-38
2005
ISSN/ISBN: 0932-0067 PMID: 16172853 DOI: 10.1007/s00404-005-0739-xDocument Number: 261384
Aim: The aim of the study was to analyze the effectiveness of the application of DDAVP (desmopressin) and Hemate P with cryoprecipitate pre- and postpartum in patients with von Willebrand disease. Methods: We monitored 32 patients with von Willebrand disease during the study period 1993-2003. DDAVP was applied in the 36th/37th week of gestation and cryoprecipitate and fresh frozen plasma were applied 1 day before and 3 days after delivery. DDAVP treatment continued for 4 weeks. Factor VIII (Hemate P) at the day of delivery Results: No complications occurred in the studied population. Conclusion: Precipitation of DDAVP, Hemate P, and cryoprecipitate may help in the treatment of pregnant women with von Willebrand disease.
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