A human autoantibody to peroxisomes
Holm, R.; Gaarder, P.I.; Helgeland, L.; Falkenhaug, E.I.
Clinical and Experimental Immunology 61(2): 305-314
1985
ISSN/ISBN: 0009-9104 PMID: 3899430 Document Number: 260792
A complement fixing, non-organ specific IgG autoantibody is described in 29 patients. The autoantibody gives a highly characteristic, granular staining of liver cells, proximal kidney tubules and stomach surface epithelium. By studies with various subcellular fractions from rat liver, employing two different techniques (quantitative complement fixation, and absorption combined with indirect immunofluorescence) the autoantibody was shown to react with a peroxisomal antigen. No convincing clinical correlations were found.