Measurement of breast volume by ultrasound during normal menstrual cycles and with oral contraceptive use
Malini, S.; Smith, E.O.; Goldzieher, J.W.
Obstetrics and Gynecology 66(4): 538-541
1985
ISSN/ISBN: 0029-7844 PMID: 3900840 Document Number: 260437
The volume of the human breast was measured by ultrasonographic methods with good reliability and reproducibility. Variations in breast volume of up to 36% were encountered with weekly measurements during the course of seven normal menstrual cycles. Oral contraceptives containing 35 to 50 micrograms ethynyl estradiol and amounts of norethindrone varying over a range of 0.4 to 2.5 mg/day and used for six cycles did not produce dose-related changes in breast volume as compared with untreated control subjects, but the sensitivity of the experiment was reduced by notable individual variation and relatively small sample sizes.