Effect of tiropramide chlorhydrate on intestinal transit time in patients with irritable colon syndrome
Passaretti, S.; Fesce, E.; Fanti, L.; Bierti, L.; Bruno, L.; Rossini, G.; Mazzotti, G.; Ideo, G.; Tittobello, A.
Minerva Medica 76(19-20): 923-926
1985
ISSN/ISBN: 0026-4806 PMID: 4000532 Document Number: 260015
The effect of tiropramide hydrochloride--a new spasmolytic drug with calmodulin-independent activity--in correcting alterations of intestinal transit, has been investigated in 40 IBS patients (20 with accelerated and 20 with delayed transit time). Intestinal transit has been evaluated by means of radioopaque markers. Tiropramide hydrochloride, at a dose of 100 mg t.i.d. for 4 weeks, was found significantly more effective than placebo both in normalizing intestinal transit time and in inducing symptomatic relief.