Construction and characterization of a full-length HIV-1 (92UG001) subtype D infectious molecular clone
Novelli, P.; Vella, C.; Oxford, J.; Daniels, R.S.
Aids Research and Human Retroviruses 18(1): 85-88
2002
ISSN/ISBN: 0889-2229 PMID: 11804560 DOI: 10.1089/088922202753394754Document Number: 259644
Here we report the construction, sequencing, and biological characterization of a molecular clone of HIV-1(92UG001), a virus representative of subtype D strains circulating in Uganda. The virus produced by the clone has an aggressive syncytium-inducing phenotype, which matches that of the parental virus. This phenotype may be related to duplication of a binding site for a transcription factor, T cell factor 1alpha (TCF-1alpha), in the long terminal repeat of the virus.
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