Cytoplasmic estrogen and progesterone receptors in primary cervical carcinoma--relation between clinical aspects and histopathology
Gao, Y.L.
Zhonghua Zhong Liu Za Zhi 7(6): 451-454
1985
ISSN/ISBN: 0253-3766 PMID: 3836850 Document Number: 258106
The measurement of cytoplasmic estrogen and progesterone receptors (ERc and PRc) as markers of specific hormone in the human breast and endometrial cancer leads to the application of receptor levels as a means in clinical management. Comprehensive investigations have not been completed in invasive cervical cancer. From 1977 to 1981, 39 cases of primary cervical carcinoma were assayed as to the presence or absence of ERc and PRc by the saturation point dextran-coated charcoal method. The level of ERc and PRc of various clinical stages, histological types, histological grades, menstrual status, age and survival was compared each other. Positive and negative receptor groups were proposed using more than or equal to 5 fmol/mg cytosol protein for ERc ane more than or equal to 10 fmol/mg cytosol protein for PRc as discrimination points. Survival of the measured patients was computed by the product-limit analysis according to Kaplan-Meier. A statistical difference between the PRc (+) and PRc (-) group in survival was noted by the Mantel-Cox test (P = 0.049). There was a longer survival in the PRc (+) patients. As to premenopausal or menopausal status, a statistical difference between the PRc (+) and PRc (-) group in survival was only observed in the premenopausal patients. The demonstration of the relationship between the PRc level and survival in cervical carcinoma would certainly be clinical significant to identify the high-risk patients for failure as treated by routine radiotherapy or surgery.