Selective decrease of hypothalamic noradrenaline by cysteamine
Vécsei, L.; Balázs, M.; Bollók, I.; Telegdy, G.
Archives Internationales de Pharmacodynamie et de Therapie 274(1): 125-128
1985
ISSN/ISBN: 0003-9780 PMID: 4015257 Document Number: 257816
In dose studies, cysteamine pretreatment in a dose of 200 mg/kg or 300 mg/kg (subcutaneously, s.c.) markedly decreased the hypothalamic noradenaline content, but did not influence the dopamine and serotonin contents. In time studies, pretreatment with cysteamine in a dose of 300 mg/kg (s.c.) led to markedly decreased hypothalamic noradrenaline contents 4 hr, 8 hr and 12 hr after treatment. These results suggest that cysteamine treatment selectively decreases the hypothalamic noradrenaline content in dose- and time-related manners.