Concentrations of antibiotics (josamycin, trioleandomycin and amoxicillin) in the secretions of the ear, sinus and adenoids
Berezin, A.; Bergogne-Berezin, E.; Martin, P.; Berthelot, G.
Annales d'Oto-Laryngologie et de Chirurgie Cervico Faciale Bulletin de la Societe d'Oto-Laryngologie des Hopitaux de Paris 102(7): 499-502
1985
ISSN/ISBN: 0003-438X PMID: 3879140 Document Number: 255852
This was a comparative study of antibiotics in the pus of otitis and from the sinuses as well as in the adenoids. Three antibiotics were chosen: Trioleandomycin, Josamycin, Amoxicillin. The study protocol was strict. Results obtained were as follows: high concentrations of macrolids in discharge of otitis and the sinuses as well as in the adenoids. Concentrations were higher than serum concentrations. By contrast, in the case of amoxicillin tissue concentrations were lower than the serum concentration. This leads to the conclusion that there is good penetration of infectious ENT sites by macrolids.