Influence of the H-2u haplotype on immune function in F1 hybrid mice. I. Antigen presentation
Fritz, R.B.; Skeen, M.J.; Ziegler, H.K.
Journal of Immunology 134(6): 3574-3579
1985
ISSN/ISBN: 0022-1767 PMID: 2580890 Document Number: 255622
The ability of myelin basic protein-primed parental or F1 T cells to respond to myelin basic protein or myelin basic protein peptides in the context of PL/J, SJL/J or F1 antigen-presenting cells was studied. It was found that the F1 T cells responded to either the protein or the peptides when these were presented in the context of F1 or PL/J antigen-presenting cells. However, F1 T cells would not respond to myelin basic protein in the context of SJL/J antigen-presenting cells, although the latter cells were functionally intact. This effect was not antigen-specific because SJL/J antigen-presenting cells would not present ovalbumin or purified protein derivative to primed F1 T cells. F1 T cells from mice immune to the strongly antigenic bacterium Listeria monocytogenes responded to bacterial antigens presented by SJL/J antigen-presenting cells, although at a significantly lower level compared with the results obtained when these antigens were presented by F1 or PL/J antigen-presenting cells. This finding implied that unbalanced antigen presentation is a quantitative rather than a qualitative phenomenon. When F1 mice from other strain combinations were tested, a similar effect was observed whenever one of the parental strains was PL/J. This effect was mapped to the H-2 complex in MHC-congenic B10 mice.