Recombination between the fragile site Xq27 and the gene for coagulation factor IX
Landoulsi, A.; de Blois, M.C.; Guérin, P.; Rethoré, M.O.; Lejeune, J.; Lucotte, G.
Annales de Genetique 28(4): 201-205
1985
ISSN/ISBN: 0003-3995 PMID: 3879429 Document Number: 254986
Using the Taq I restriction polymorphism of a factor IX probe, we analysed the segregation of this gene and that of the fragile site Xq27. The ancestor of this family was a healthy carrier male. Of twelve informative meioses, at least four recombinations were detected. The hypothesis of a particular instability of the distal part the long arm of the X chromosome is reconsidered.
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