Glycerol release from incubated human adipocytes is not affected by gastrointestinal peptides
Richter, W.O.; Schwandt, P.
International Journal of Obesity 9(1): 25-27
1985
ISSN/ISBN: 0307-0565 PMID: 4019016 Document Number: 254301
There is evidence for involvement of gastrointestinal hormones in pathogenesis of obesity and reports on lipolytic activity in animals. The in vitro lipolytic activity of these hormones was tested in human adipocytes. Vasoactive intestinal polypeptide, glucagon, secretin, human gastrin I, gastrin releasing polypeptide, gastric inhibitory polypeptide, pancreatic polypeptide, motilin, bombesin, neurotensin, C-peptide, as well as cholecystokinin did not stimulate lipolysis significantly above basal. These results indicate that the involvement of these hormones in obesity in man might not be due to a direct lipolytic effect on the human adipocyte.