The disconnect between a national tuberculosis drug resistance survey and treatment outcomes: a lost opportunity
Click, E.S.; Chirenda, J.; Kibias, S.; Menzies, H.J.; Oeltmann, J.E.; Sentle, C.; Muribe, T.; Lere, T.D.; Makombe, R.; Bamrah, S.; Moore, B.K.; Cain, K.P.
International Journal of Tuberculosis and Lung Disease the Official Journal of the International Union Against Tuberculosis and Lung Disease 18(11): 1319-1322
2014
ISSN/ISBN: 1027-3719 PMID: 25299864 DOI: 10.5588/ijtld.13.0710Document Number: 254237
We linked results from the Fourth Botswana National Drug Resistance Survey (DRS), 2007-2008, to patient records from the national Electronic Tuberculosis Registry to determine treatment outcomes. Of 915 new patients, 651 (71%) had treatment data available. Completion or cure was achieved for 10/15 (67%, 95%CI 42-85) with isoniazid monoresistance, (6/16, 38%, 95%CI 18-61) with multidrug resistance, while 73% (391/537, 95%CI 69-76) were susceptible to first-line drugs. The analysis was limited because of unavailable treatment records and undocumented outcomes. Prospective analyses following DRSs should be considered to ensure adequate outcome data.