Surveillance of drug resistance to anti-tuberculosis drugs in districts of Hoogli in West Bengal and Mayurbhanj in Orissa
Mahadev, B.; Kumar, P.; Agarwal, S.P.; Chauhan, L.S.; Srikantaramu, N.
Indian Journal of Tuberculosis 52(1): 5-10
2005
ISSN/ISBN: 0019-5707 Document Number: 253915
The levels and pattern of resistance to antituberculous agents among newly diagnosed sputum smear-positive pulmonary tuberculosis cases from Mayurbhanj district, Orissa, and Hoogli district, West Bengal, India were measured. Of 693 smear-positive specimens subjected to culture, 545 (78.6%) were culture-positive for Mycobacterium tuberculosis, 62 (8.9%) were culture-negative and 86 (12.4%) were contaminated. The level of resistance to any drug was 5.3% in Mayurbhanj district and 16.7% in Hoogli district. The resistance level to 4 drugs (isoniazid, rifampicin, ethambutol and streptomycin) in Mayurbhanj district ranged from 0.4% to 3.9%, and in Hoogli district, 1.9-13.7%. Multiple drug resistance was 0.7% (95% confidence interval (CI), 0.0-1.7%) and 3.0% (95% CI 1-5.1%) in Mayurbhanj and Hoogli districts, respectively.