Multicentric giant lymph node hyperplasia, Kaposi's sarcoma, and lymphoma
Dickson, D.; Ben-Ezra, J.M.; Reed, J.; Flax, H.; Janis, R.
Archives of Pathology and Laboratory Medicine 109(11): 1013-1018
1985
ISSN/ISBN: 0003-9985 PMID: 3840353 Document Number: 253429
We studied two cases of a recently recognized systemic lymphoproliferative disease with morphological features of Castleman's disease: multicentric giant lymph node hyperplasia. Both patients developed Kaposi's sarcoma and had laboratory evidence of immune abnormalities, including reversed T4 to T8 ratios. One patient's disease had a subacute course with fevers of unknown origin, mucocutaneous candidiasis, and progressive thrombocytopenia, while the other patient's disease had a fulminant course with anemia, thrombocytopenia, and splenic lymphoma. Both patients were elderly, and both died of complications of multicentric giant lymph node hyperplasia.