Cardial decompensation caused by hypertension and polyglobulia associated with multiple renal oncocytomas
Stefenelli, T.; Silberbauer, K.; Ulrich, W.; Sommeregger, K.; Zechner, O.
Clinical Nephrology 23(6): 307-311
1985
ISSN/ISBN: 0301-0430 PMID: 4028530 Document Number: 252697
A 43 yr old man was referred to the Internal Department [University of Vienna] for the examination of cardial decompensation, hypertension, polyglobulia and atrophy blanch of the lower legs. Clinical and supersonic examination revealed 2 tumors in the left kidney (diameter 8 and 3.5 cm) and some small tumors in the right kidney. Laboratory studies disclosed erythropoietin levels up to 170 mU/ml (standard 14-61 mU/ml) and a red blood cell count of up to 8 .times. 106/ml. After recompensation, a radical left nephrectomy and the removal of 3 small tumors of the right kidney 4 wk later was initiated. Postoperative erythropoietin levels and red blood cell count sank to the normal range leading to the reduction of antihypertensive therapy. The clinical course indicates a strong etiological connection between hypertension as well as polyglobulia with the multiple bilateral oncocytomas. Polycythemia also led to the atrophy blanch which had resulted from disturbances of microcirculation.