Changes in haemostasis during normal pregnancy
Uchikova, E.H.; Ledjev, I.I.
European Journal of Obstetrics Gynecology and Reproductive Biology 119(2): 185-188
2005
ISSN/ISBN: 0301-2115 PMID: 15808377 DOI: 10.1016/j.ejogrb.2004.06.038Document Number: 252198
(1) To study the changes in the haemostatic variables during normal pregnancy, and (2) to compare them with the corresponding variables in a control group of nonpregnant women. University Hospital. The study involves two groups of women: pregnant women (in 35th-40th gestational weeks (GW)) (N = 35) and a control group of nonpregnant women (N = 35). We examined the global tests, the variables relating to coagulation and fibrinolysis and the group of natural inhibitors of coagulation, and compared them between the two groups. The pregnant women had statistically significantly higher values for: prothrombin time (PT) (P < 0.0001), thrombin time (TT) (P < 0.0001), fibrinogen (P < 0.0001), activity of factor VII (P < 0.0001), factor X (P < 0.0001) and alpha2-antiplasmin (P < 0.002), plasma concentration of D-dimer (plsDD) (P < 0.0001) and activity of heparin cofactor II (HCII) (P < 0.002). They had statistically significantly lower activity of protein C (PrC) (P < 0.0001) and of total protein S (TPrS) (P < 0.0001). During normal pregnancy the activation of coagulation is counterbalanced by the activation of fibrinolysis, which maintains the haemostatic balance.
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