Radioimmunoassay of serum bile acids in normal pregnancy and in recurrent cholestasis of pregnancy
Samuelson, K.; Thomassen, P.A.
Acta Obstetricia et Gynecologica Scandinavica 59(5): 417-420
1980
ISSN/ISBN: 0001-6349 PMID: 7446006 Document Number: 167025
Radioimmunoassay [RIA] was used to quantitate the conjugates of cholic and chenodeoxycholic acid in venous blood from women in different stages of normal pregnancy, and in patients with recurrent intrahepatic cholestasis of pregnancy (RCP). The levels of cholic and chenodeoxycholic acid were within normal limits throughout uncomplicated pregnancy, and elevated in RCP. Because of RIA simplicity and reliability, it is suggested that this method can be used to detect and follow the course of RCP, and to assess the possible influence of treatment, e.g., diet.