Quantitative analysis of the ultrastructure of gastric mucocytes in the rat after prostaglandin treatment
Kiseleva, E.V.; Vorontsova, L.A.; Khristoliubova, N.B.; Tairov, M.M.; Argutinskaia, S.V.
Arkhiv Anatomii Gistologii i Embriologii 88(1): 82-85
1985
ISSN/ISBN: 0004-1947 PMID: 3856422 Document Number: 252128
Effect of prostaglandin E2 (PGE2) on mucus secretion by mucocytes of the fundal part of the rat stomach has been studied electron microscopically, morphometrically and biochemically. PGE2 is found to stimulate synthesis of glycoproteins and their secretion by the mucocytes that results in increasing the relative volume of Golgi complex and in decreasing that of secretory granules. Actinomycin does not affect and cycloheximide blocks the stimulating activity of prostaglandin. This demonstrates that prostaglandin produces its action at the posttranscriptional (translational) level controlling mucus secretion of mucocytes. Owing to the results of the investigation and of those previously obtained on incorporation of 3H-pentagastrin and 3H-histamine into the cells of the mucous tunic, at least two mechanisms are supposed to control the gastric mucus secretion.