Diffuse cutaneous vasculitis disclosing acute lymphoblastic leukemia
Marandian, M.H.; Soltanabadi, A.; Rakchan, M.; Vessal, P.; Lessani, M.; Fallah, A.
Pediatrie 40(3): 229-233
1985
ISSN/ISBN: 0031-4021 PMID: 3862061 Document Number: 252108
Biopsy of skin for etiologic evaluation of generalized erythematous eruptions in a 4 1/2 years old child, starting four months ago, led to diagnosis of acute lymphoblastic leukemia. Leukocyte counts five and eight weeks and four months after appearance of eruptions were normal and no blasts were found. A leukocyte count performed simultaneously with biopsy of skin also showed few (less than 10%) blasts. Histologic examination of skin revealed two types of pathologic lesions: a perivascular cuffing of lymphoblasts and a leukocytoclastic type of small vessel vasculitis in other parts. This type of vasculitis which have been reported in association with chronic lymphocytic and hairy cell leukemias, is uncommon in acute lymphoblastic leukemia.