Myocardial morphology in endotoxic shock
Iakovlev, M.I.
Arkhiv Patologii 47(7): 34-41
1985
ISSN/ISBN: 0004-1955 PMID: 4051813 Document Number: 251201
The myocardium of rabbits with endotoxin shock produced by two intravenous injections (0.1 and 0.3 mg/kg) of the typhoid fever bacillus antigen was studied histologically, histochemically, histoenzymatically and by polarization microscopy. Animals were killed by decapitation 0,5-1,5, 5-10, 24-30, 48-80, 120-194 hours after the 2nd injection; animals dying in the course of experiment were also examined. Morphological substrate of heart insufficiency, morphofunctional heterogeneity of cardiomyocytes of both inner and external myocardial layers were revealed. Hypoxia of a complex origin is the main cause of the above alterations.