Antigen specific human T cell clones: heterogeneity of specificity and function
Rees, A.D.; Knott, G.; Lamb, J.R.
Behring Institute Mitteilungen 77: 75-81
1985
ISSN/ISBN: 0301-0457 PMID: 2417585 Document Number: 250985
Human T cell clones specific for either mycobacterial or viral antigens have been generated and characterized. Different antigenic structures were recognized by T cells which had specific functions. These appeared to be directed at a number of target effector cells. Even where a number of T cell clones mediated the same function variation in clonal products suggested this might be achieved by different mechanisms. The multiplicity of immune function displayed by these T cell clones is discussed in the context of their antigenic specificity and genetic restriction.