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Influence of testosterone on morphine analgesia in albino rats

Rao, S.S.; Saifi, A.Q.

Indian Journal of Physiology and Pharmacology 29(2): 103-106

1985

ISSN/ISBN: 0019-5499
PMID: 4093190
Document Number: 248107
Pain threshold for thermal stimulus after morphine, naloxone alone and naloxone in combination with morphine was studied in male rats before and after three days treatment with testosterone. It was also determined 15 days after gonadectomy and aministration of testosterone in such rats. There was significant reduction in morphine analgesia after administration of testosterone and also after gonadectomy. Naloxone increased the pain threshold in gonadectomized rats and its enhanced morphine induced analgesia instead of antagonizing it. Naloxone, however, had no effect on morphine analgesia in testosterone treated control rats and gonadectomized rats.

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