Development of a high fibrinolytic potential around a thrombus using leukocyte Fc receptors loaded with streptase
Tsybikov, N.N.; Kuznik, B.I.; Lozhkina, A.N.; Kradenov, A.V.
Biulleten' Eksperimental'noi Biologii i Meditsiny 100(11): 581-583
1985
ISSN/ISBN: 0365-9615 PMID: 4063507 Document Number: 247840
An effective way of inducing high fibrinolytic potential in the thrombus area by streptase-containing leucocytes has been suggested. Leucocytes were incubated with streptase and then placed in the solution containing a fibrin clot, the latter pre-treated with anti-fibrin serum. In these conditions the rate of fibrinolysis increased drastically. The authors believe that fibrinolysis is initiated by the interaction of activated leucocytes via Fc-receptors with fibrin and the release of endo- and exogenic fibrinolytic proteases.