Effects of SKF 525-A, phenobarbital and 3-methylcholanthrene on the toxicity of lobeline sulfate
Kim, H.L.
Veterinary and Human Toxicology 27(1): 1-2
1985
ISSN/ISBN: 0145-6296 PMID: 3976162 Document Number: 247629
The i/p LD50 of lobeline sulphate following SKF 525-A (75 mg/kg), phenobarbital, and 3-methylcholanthrene was 18.3, 85.5 and 82.1 mg/kg, respectively, compared to 55.3 mg/kg in saline treated controls. Pretreatment of mice with disulfiram, diethylmaleate, or ethoxyquin hydrochloride exhibited a very slight effect on the toxicity of lobeline sulphate. These results suggest that the hepatic microsomal monooxygenase system, but not glutathione, is involved in the detoxication of lobeline sulphate.
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