Effect of serotonin on proliferating and resting cells in culture
Nefedov, V.P.; Kulinskiĭ, V.I.; Andreeva, T.V.
Tsitologiia 27(9): 1043-1048
1985
ISSN/ISBN: 0041-3771 PMID: 4060229 Document Number: 247460
The influence of exogenous serotonin on cell division of L929 and L-41 cell strains has been investigated under various conditions of cell growth in culture (the incubation either in 10% serum medium without changing the medium, or in the medium with 0.5% serum). The data obtained show that serotonin in physiological concentration (10(-7) M) stimulates proliferation of resting cells. In proliferating cells, compared to resting ones, the sensitivity to exogenous amine appeared statistically non-significant. Exogenous serotonin is suggested to be a proliferating stimulus for resting cells.
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