HLA antigens in ovarian adenocarcinoma patients
Illeni, M.T.; Pasquali, M.; La Monica, G.; Böhm, S.; Rovini, D.; Di Re, E.
European Journal of Gynaecological Oncology 6(2): 121-125
1985
ISSN/ISBN: 0392-2936 PMID: 3875487 Document Number: 247440
Sixty five patients affected by ovarian carcinoma, 40 controls with benign ovarian disease were typed for HLA A, B and C antigens and compared with 132 adult female blood donors. A highly significant increase in HLA B7 antigen (p = 0.0083) and a decrease in HLA A11, A28, B12 (p = 0.04; p = 0.001; p = 0.03, respectively) in patients vs. controls has been noticed. The comparison among the ovarian benign disease patients, and those with ovarian carcinoma and the healthy controls showed a decrease in the HLA A1 antigen frequency. Besides the patients presented an increased and a decreased frequency of the A and O blood phenotypes, respectively. These data confirm those of other Authors, and we can conclude that the neoplastic disease does not show a strong association with histocompatibility antigens.