Inhibition of calcium uptake by capsaicin
Monsereenusorn, Y.; Kongsamut, S.
Research Communications in Chemical Pathology and Pharmacology 47(3): 453-456
1985
ISSN/ISBN: 0034-5164 PMID: 3992020 Document Number: 246881
The effects of capsaicin on 45Ca2+ uptake were studied in cultured rat aortic smooth muscle and mouse neuroblastoma cell lines. Capsaicin (up to 300 microM) caused a dose-dependent inhibition of 45Ca2+ uptake both under resting (5 mM K+) and depolarizing (50 mM K+) conditions in both cell lines. These results provide one possible mechanism of action of capsaicin.
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