Circadian fluctuations in dioxidine toxicity
Gus'kova, T.A.; Liberman, S.S.
Farmakologiia i Toksikologiia 48(1): 80-82
1985
ISSN/ISBN: 0014-8318 PMID: 3979543 Document Number: 246306
It has been established in rat experiments that toxicity of the antibacterial drug dioxydin (1,4-di-N-oxide 2,3-dioxymethylquinoxaline) depends on the time of administration. The drug exhibits the minimal and maximal toxicity upon administration at 8 o'clock p.m. and at 12 o'clock, respectively.
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