Hepatic hemodynamic changes (flowmetry and manometry) during extracorporeal circulation, in normo- and hypothermic conditions, with and without hemodilution. Experimental study in dogs
De Oliveira, R.A.; Silva, M.A.; de Andrade, R.R.; de Pinho, S.Z.; Curi, P.R.; Hossne, W.S.
Arquivos Brasileiros de Cardiologia 44(5): 311-317
1985
ISSN/ISBN: 0066-782X PMID: 4091727 Document Number: 246027
Manometric and fluxometric studies of the hepatic circulation were made during cardio-pulmonary bypass in 49 dogs. The animals were divided into four groups, considering the body temperature and the perfusion solution. Group I (n = 7) - normia without hemodilution; group II (n=7) - normothermia with hemodilution; group III (n=7) - hypothermia with hemodilution. The temperature did not influence the perfusion flow provided by the extracorporeal circulation. Moreover the perfusion flow obtained during hemodilution was significantly higher. Arterial pressure was not influenced by temperature nor hemodilution in the four groups. Cardio-pulmonary bypass provoked, in all the dogs, an elevation of the portal vein pressure independently of temperature or hemodilution. Hepatic arterial blood flow did not change under the same conditions. It was concluded that temperature was a predominant factor in influencing hepatic blood flow. Thus, in the group III (hypothermia without hemodilution), the portal vein flow and the total hepatic flow were significantly higher in comparison with the other groups.