Current contraceptive research
Benditt, J.M.
Family Planning Perspectives 12(3): 149-155
1980
ISSN/ISBN: 0014-7354 PMID: 6995149 DOI: 10.2307/2134569Document Number: 245365
A broad sampling of current contraceptive research was presented at a recent scientific meeting attended by clinicians, researchers, and program personnel in Mexico City. This article identifies several of the most promising developments, explains their mode of operation, provides details of the research underway on them, and assesses the feasibility of workable methods of contraception based on them. The most promising involves testing of manmade analogs of luteinizing hormone-releasing hormone (LHRH), a brain hormone, which has potential for suppressing ovulation and inducing menstruation in women as well as blocking sperm production in men. Another possibility is gossypol, a derivative of cottonseed oil developed as a male contraceptive by the Chinese. Testosterone in sufficient quantity can lead to sharp reductions in sperm production by means of a feedback mechanism, but difficulties have been encountered in route of administration and side effects. 2 female injectables are being tested in clinical trials by the World Health Organization: a progestin-only product is being compared to Depo Provera in a large international clinical trial, and another containing both a progestin and an estrogen is about to begin trials. A vaginal ring and an intracervical device are designed to provide controlled local release of progestins, thicken cervical mucus and interfere with sperm transport. 2 chemical agents which cause early abortion may be close to human use.