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Isolation of a lymphadenopathy-associated virus from a patient with the acquired immune deficiency syndrome

Becker, M.L.; Spracklen, F.H.; Becker, W.B.

South African Medical Journal 68(3): 144-147

1985

ISSN/ISBN: 0256-9574
PMID: 2992103
Document Number: 245309
A virus similar to the lymphadenopathy-associated virus or human T-lymphotropic virus type III, which has been described in association with the acquired immune deficiency syndrome (AIDS) by several laboratories elsewhere in the world, was isolated from a Cape Town patient with lymphadenopathy and acquired immune deficiency. This virus has the characteristic morphogenesis and ultrastructure and its genome encodes the virus-specific p24 protein. It is T-lymphotropic and produces the characteristic cytopathic effect. It can be serially propagated in a human lymphocyte line of the T4+ phenotype. This isolate is being used in diagnostic immunofluorescence assays for virus-specific antibodies.

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