Primary cardiac angiosarcoma with systemic metastases; a case report and review of the literature
Larbcharoensub, N.; Singhsnaeh, A.; Leelachaikul, P.
Journal of the Medical Association of Thailand 87(9): 1116-1122
2004
ISSN/ISBN: 0125-2208 PMID: 15516016 Document Number: 2453
Angiosarcoma is a relatively uncommon primary malignant tumor of the heart derived from the endothelial cells. The authors report a case of primary cardiac angiosarcoma of the right atrium with pulmonary, hepatic, cerebellar and bony metastases in a 46-year-old man who clinically presented as pulmonary hemorrhage. The patient's occupational history had occasional exposure to polyvinyl chloride. The autopsy examination of the cardiac angiosarcoma characterized macroscopically by a right atrial tumor and histologically by anastomosing vascular channels and minute atypical pleomorphic endothelial cells. Immunohistological stainings were positive CD31, CD34 and focal positive factor VIII-related antigen. Clinical and pathologic features with briefly reviewed relevant literatures are discussed. This is the first reported description in the literature of a primary cardiac angiosarcoma with systemic metastases to multiple organs in Thailand.
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