Effect of a risk of malignancy index in preoperative diagnosis of ovarian cancer
Ma, S.; Shen, K.; Lang, J.
Zhonghua Fu Chan Ke Za Zhi 36(3): 162-164
2001
ISSN/ISBN: 0529-567X PMID: 11783394 Document Number: 244762
To evaluate the ability of a risk of malignancy index (RMI), based on a serum CA125 level, ultrasound findings and menopausal status, to discriminate a benign from a malignant pelvic mass. One hundred and forty women with a pelvic mass, 30 years or older, admitted between January 1998 and June 1999, were studied. The sensitivity, specificity and positive predictive value of serum CA125 level, ultrasound findings and the menopausal status separately and combined into the RMI, to diagnose ovarian cancer. RMI was more accurate than any individual criterion in diagnosing cancer. Using a RMI cut-off level of 200 to indicate malignancy, the RMI derived from this data set gave a sensitivity of 87.3%, specificity of 84.4%, and positive predictive value of 82.1%. RMI is able to correctly discriminate between malignant and benign pelvic mass. It can be introduced easily into clinical practice to facilitate the selection of patients for primary surgery.