Power of isoniazid acetylation and pigmentation; first experimental tests in the rabbit: comparison with clinical data
Leperchey, F.; Vivien, J.N.; Vicaut, E.; Galliot, M.; Deplus, S.; Gervais, P.
International Journal of Clinical Pharmacology Research 5(4): 283-286
1985
ISSN/ISBN: 0251-1649 PMID: 4055169 Document Number: 243904
A positive correlation has been observed clinically at the Centre Edouard Rist, Paris, between the degree of pigmentation and the power of isoniazid acetylation in so-called "caucasians". The investigation was based on a relatively small sample of 153 observations, but sufficient to allow a significant statistical analysis. Comparing the results with data published in the literature, it may be assumed that this relationship between the power of acetylation and pigmentation would be applicable to all human beings. The rabbit, having as in man a bi-modal distribution of the power of acetylation, was used for further research of this correlation in that animal. The results of this research in rabbits may be compared with those in man, but further studies are required in view of the interest of this comparison and of the possible consequences of the relationship of pigmentation and the degree of acetylation of isoniazid in human therapeutics.