Failure of cis-platinum to alter metal concentrations in the liver and kidney of the rat
Kinsler, S.; Bell, J.U.
Biochemistry International 10(6): 847-853
1985
ISSN/ISBN: 0158-5231 PMID: 4041185 Document Number: 243214
The anticancer drug, cis-diamminedichloroplatinum, was administered to male rats at a dose of 0.5, 1.0, 2.0 or 4.0 mg platinum/kg body weight. After 48 hrs, the animals were killed and platinum, zinc, copper and metallothionein were measured in renal and hepatic tissue and platinum, zinc and copper were measured in the plasma. Administration of this platinum-containing compound did not induce hepatic or renal metallothionein and did not significantly alter the concentrations of copper or zinc in hepatic or renal tissue or in the plasma.