Effect of progesterone on the ion-regulating function of the kidneys
Kukharchuk, A.L.; Gozhenko, A.I.
Problemy Endokrinologii 31(2): 55-58
1985
ISSN/ISBN: 0375-9660 PMID: 3991487 Document Number: 242982
The effect of progesterone on ion-regulating kidney function was studied in experiments on albino male rats under the conditions of spontaneous and water diuresis. Kidney function was evaluated by the level of urination, sodium, potassium and creatinine excretion with regard to the glomerular filtration and tubular reabsorption in water diuresis. Five series experiments were made, including a study of the effect of progesterone on kidney function under the conditions of a low and high sodium diet, adrenalectomy and castration. Progesterone was shown to possess a pronounced natriuretic effect in sodium deficiency in the body and to cause sodium retention in a high sodium diet. Adrenalectomy and castration did not prevent the natriuretic action of progesterone. The elevated excretion of sodium was determined by an increase in its filtration charge. In all the studies sodium excretion changed with a sufficient degree of significance (P less than 0,01 = PI less than 0,05).