Structural restriction in bile acids and non-ionic detergents for promotion of heparin absorption from rat gastro-intestinal tract
Guarini, S.; Ferrari, W.
Archives Internationales de Pharmacodynamie et de Therapie 271(1): 4-10
1984
ISSN/ISBN: 0003-9780 PMID: 6497508 Document Number: 241684
Selected nonionic surfactants of the polyoxyethylene ether series as well as selected bile acids elicit plasma clearing activity (PC) after oral heparin administration by action on the gastrointestinal mucosa. Certain structural characteristics evidently are needed for promoting heparin absorption, since this effect is observed with some but not all nonionic detergents (cetyl and stearyl ethers but not lauryl) and bile components (deoxycholic, chenodeoxycholic and cholic acids, but not ursodeoxycholic or dehydrocholic acids or lecithin). A specific mechanism of action apparently is involved.