Hyperlipidemia related to the use of HIV-protease inhibitors: natural history and results of treatment with fenofibrate
Caramelli, B.; de Bernoche, C.Y.; Sartori, A.M.; Sposito, A.C.; Santos, R.D.; Monachini, M.C.; Strabelli, T.; Uip, D.
Brazilian Journal of Infectious Diseases An Official Publication of the Brazilian Society of Infectious Diseases 5(6): 332-338
2001
ISSN/ISBN: 1413-8670 PMID: 11980596 DOI: 10.1590/s1413-86702001000600007Document Number: 241672
Hyperlipidemia has been frequently recorded as a side effect of treating HIV patients with protease inhibitors (PI). This study was initiated to analyze the modifications on blood lipids in HIV-patients receiving PI and the safety and efficacy of the treatment with fenofibrate. Total (TC) and HDL-cholesterol, triglycerides (TG), and CD(4)(+) T-cell counts were measured in 30 HAART-naive patients (Group I) before and after PI introduction. In a second phase of the study, the effects of fenofibrate on lipids, CPK, CD(4)(+), and viral load were determined in 13 patients (Group II) with elevated TC or TG. In Group I, 60% of the patients showed TC or TG elevations. Average increments of 31% and 146% in TC and TG respectively (p<0.0006 and p<0.0001) were observed. In Group II, fenofibrate treatment was associated with decrements of 6.6% (TC) and 45.7% (TG) (p=0.07 and 0.0002) and no modifications on CPK, CD(4)(+), and viral load. In conclusion, hyperlipidemia is common during the treatment of HIV with protease inhibitors, and fenofibrate appears to be an effective and safe choice for its treatment.